Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up

Genome Wide Association Studies, Next Generation Sequencing and Their Application in Animal Breeding and Genetics: A Review

Recently genetic studies have been revolutionized by next generation sequencing (NGS) technology, and it is expected that the use of this technology will largely eliminate defects in the methods of association studies. The NGS technology is becoming the premier tool in genetics. However, at the moment the use of this method is limited especially in the livestock due to high cost and computation...

Advances in Genetics Moving Beyond Genome-Wide Association Studies

The sequencing of the human genome1 and the subsequent completion of the human haplotype mapping (HapMap) project2 have led to unparalleled research into the structure and biology of the genome. These milestones held the promise of revolutionizing our understanding of the genetic basis for human disease, with the hope that population research would quickly lead to improved screening and diagnos...

Genome-wide association studies: understanding the genetics of common disease

Copy number variation accuracy in genome-wide association studies.

BACKGROUND/AIM Copy number variations (CNVs) are a major source of alterations among individuals and are a potential risk factor in many diseases. Numerous diseases have been linked to deletions and duplications of these chromosomal segments. Data from genome-wide association studies and other microarrays may be used to identify CNVs by several different computer programs, but the reliability o...

Replication of Genome Wide Association Studies of Alcohol Dependence: Support for Association with Variation in ADH1C

Genome-wide association studies (GWAS) have revealed many single nucleotide polymorphisms (SNPs) associated with complex traits. Although these studies frequently fail to identify statistically significant associations, the top association signals from GWAS may be enriched for true associations. We therefore investigated the association of alcohol dependence with 43 SNPs selected from associati...